Investigation of Stress Response Genes in Antimicrobial Resistant Pathogens Sampled from Five Countries

Pathogens, which survive from stressed environmental conditions and evolve with antimicrobial resistance, cause millions of human diseases every year in the world. Fortunately, NCBI Pathogen Detection Isolates Browser (NPDIB) collects detected stress response genes resistance pathogen isolates sampled around While several studies have been conducted to identify important genes, little work has done analyze NPDIB database. In order address this, this first comprehensive statistical analysis five countries major residential continents, including US, UK, China, Australia, South Africa. Principal component was project onto a two-dimensional space, hierarchical clustering then implemented outlier (i.e., important) that show high occurrences historical data 2010 2020. Stress AMR were finally analyzed together investigate co-occurring relationship between these two types genes. It turned out seven commonly found all arsR, asr, merC, merP, merR, merT, qacdelta1). Pathogens E. coli Shigella, Salmonella enterica, Klebsiella pneumoniae pathogens carrying The result showed certain grouped together, golT~golS mdsB~mdsC, ymgB mdtM, qacEdelta1 sul1. occurrence samples containing three had highest detection frequency data. findings on along their connection could inform future drug development targets weaken pathogens.